One of the natural materials as potentially efficacious chemopreventive agents are Ciplukan (Physalis angulata L.). Several previous studies reported that Physalis angulata L. herbs ethanolic extract (PEE) has cytotoxic activity and induction of apoptosis in breast cancer cells MCF-7 and HeLa cervical cancer cells. This study aims to determine the effects of PEE as an chemopreventive agent on …
Hesperidin, a flavonoid, shows strong cytotoxic effect in several cancer cell lines. The aim of this research was to investigate cytotoxic activities of hesperidin alone and in combination with doxorubicin. Cell viability assay of hesperidin, doxorubicin, and combination treatments were carried out by using 11 MTT assay. Apoptosis assay was done using double staining method using Ethidium Brom…
Makassar fruit, Brucea Javanica (L) Merr., showed chemopreventive activity. Secondary metabolites come from B. Javanica fruit, brucatol g/mL dan 148 nM, respectively. Both of BF and doxorubicin showed apoptosis induction on IC50. Combination of BF-doxoand bruceantine, induced cell differentiation and apoptosis on Leukemia cell, while quessioid and its derivates acted as antitumor promoter. Buta…
Areca (Areca catechu L.) seeds ethanolic extract shows cytotoxic activity against MCF-7 cells. The aim of this research is to examine the cytotoxic effect, apoptosis induction andtarget on bcl-2 expression in MCF-7 cells of A. catechu chloroform fraction (ACF). The A. catechu seed powders were extracted by using ethanol 96%. Then, the extract was fractioned with partition by hexane, chloroform,…