Makassar fruit, Brucea Javanica (L) Merr., showed chemopreventive activity. Secondary metabolites come from B. Javanica fruit, brucatol g/mL dan 148 nM, respectively. Both of BF and doxorubicin showed apoptosis induction on IC50. Combination of BF-doxoand bruceantine, induced cell differentiation and apoptosis on Leukemia cell, while quessioid and its derivates acted as antitumor promoter. Buta…