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Prostaglandin (PG) has been reported to be an important protective and acid suppressive factor in the gastric mucosa. The objective of the study was to develop and evaluate a stomach specific drug delivery system for controlled release of Misoprostal a PE analogue for gastric ulcer induced NSAIDs. Floating microspheres were prepared by emulsification-solvent evaporation method using ethyl cellu…
Ribosome Inactivating Proteins (RIPs) are compounds isolated from plants with ability to inhibit protein synthesis. The inhibition of protein synthesis is due to inactivation of ribosomal RNA through a site-specific deadenylation mediated by RNA N -g lycosid a se . Reportedly, RIPs mainly possess wide range of bioactivity including antiviral activity against plant infections. Other activities o…
The study was designed to study the Biological importance and nutritional benefits of PeriIla frutescence plant. This plant has very high biological activities. It contains various phyto-constituents such as different phenolic compounds (like rosemarinic acids, luteolin chrysoeriol, quercetin, catcehin, apigenin, etc), vitamins, minerals etc. PeriIla seeds contained 30- 40% fixed oil, contained…
Some aspects of Anopheles barbirostris behavior in Central Sumba Regency was conducted in July– October in District Umbu Ratu Nggai (Village Padira Tana) which represents in mountain ecology and the district of Mamboro (Manu Wollu Village) representing the coastal ecology. Both villages are selected to have high malaria cases during the past year. The objective of the study is to determine So…
Interest in amorphous pharmaceutical systems is steadily growing over the last 10 years. The amorphous state is critical in determining the solid state, physical and chemical properties of many pharmaceutical dosage forms. The main reason of the growing interest toward amorphous materials is the need to improve the bioavailability of drugs with poor aqueous solubility. Many drugs exist in cryst…
Quality assurance of malaria microscopy is an important issue in health service and health research for a better case management. In monitoring Dyhydroartemisinin-Piperaquine, quality assurance was a part of this research activities at sentinel sites in Kalimantan and Sulawesi. This activity was carried out to confirmed diagnosis of malaria cases that could be analysed, and to evaluate the skil…
The bis-spiroepoxide dithiane dioxide has been attempted to be synthesised as its role as an intermediate in the synthesis of diaminopimelic acid (DAP). The first method was carried out by reacting the 3-dithiane-2- diethylphosphonate 4 with an aqueous solution of the commercially available glutaraldehide resulting the bis-ketene dithiane dioxide 5. The second alternative method was involving t…
Captopril is a selective- Inhibitor of angiotensin-convertinq enzyme (ACE) and is formulaned by, several pharmaceuical companies: irr Lndonesia. This stwdy was corrducted to compare tlhe bioavailability of captopril' tablet with reference preducts in healthy volunteers. The relative bioavailability of captopril was deterrnined in single dase, randomized, crcssover, and two-phase studies. The re…
Persayaratan kualitas Air kolam Renang terakhir ditetapkan dengan Peraturan Menteri Kesehatan Nomor 416 tahun 1990. Kemajuan ilmu pengetahuan dan peningkatan kebutuhan manusia akan kesehatan, kenyamana dan relaksasi mendorong kebutuhan akan kualitas air kolam renang yang lebih baik, beberapa peristiwa infeksi penyakit menular pernafasan mencurigai ditularkan oleh air kolam renang khususnya yan…
Background: An adequate intake of iodine cause one of public health problem in Indonesia community. One way to overcome this problem is through the use of iodized salt. The uses of salt in community beside in the cooking of food also use in food preservation such as the salted eggs. Objective: The objective of this study was to observe the iodine content of the salted eggs which proceed by usin…