Artemisinin via overproduction of free radical acts as a potent drug against multi-drug resistant Plasmodium. because of new permeation pathway evidence at parasitized red blood cell membrane, L ascorbic acid as hydrophilic antioxidant hopefully can’t penetrate the membrane so that it won’t interfere the artemisinin antimalarial effect rather it protects the host cell out of parasitized ery…
Malaria is a public health problem in Indonesia. One of the problems encountered in the elimination of malaria is the resistance of Plasmodium against antimalaria drugs. Artemisinin (ACT) is aclass of antimalarial drugs that are schizonticide sesquiterpenes lactone blood for Plasmodium falciparumand P. vivax. ACT is a drug of choice for treatment in the malaria elimination program, due to the w…
Artemisinin is the besi antimalaria for chloroquine resistant P. falciparum recommended by WHO in a combination therapy. Artemisnin is isolated from Artemisia annua L (family: Asteraceace) that can grow as is should be I Indonesia and has cultivated by BPTO Tawangmangu in order to self-material antimalaria. One of the important analysis is method for measuring artemisinin concentration in extra…
Cerebral and lung during malaria infection is believed to be caused by free radicals activities that are produced during immunology process. The free radicals reacts with lipid component of cellular membrane which generates malondialdehyde (MDA) at its end-product. The aim of the research was to determine whether combination of artemisinin and NAC was more effective in decreaseing cerebral and …