Abstract Introduction: Artemis inin in artemisinin based combination therapy (ACT) was used to over¬come the resistance caused by free radical overproduction. Xanthone as antioxidant can also inhibit in vitro heme polymerization, therefore it is predicted has anti-malaria activity. The aim of this study is to evaluate the potency of alpha mangostin, gamma mangostin, garcinone C, and garcinone…
Artemisinin via overproduction of free radical acts as a potent drug against multi-drug resistant Plasmodium. because of new permeation pathway evidence at parasitized red blood cell membrane, L ascorbic acid as hydrophilic antioxidant hopefully can’t penetrate the membrane so that it won’t interfere the artemisinin antimalarial effect rather it protects the host cell out of parasitized ery…