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Apoptosis in Ipsilateral Kidney; Comparison Between Group Receiving Verapamil and Control Group Post Artifical Total Unilateral Ureteral Obstruction

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Obstruction of the urinary tract has marked effects on renal blood flow glomerular filtration rate (GFR). And tubular function. Ureteral obstruction results in an injury response that can progress to irreversible renal fibrosisand tubular damage by apoptosis. Forty five rabbits aged 13-17 weeks with body weights of 1250-1750 grams were devided into 4 groups. Group 1 underwent a sham operation and group 2 had unilateral ureteral ligation to cause total obstruction. Group 3 and 4 also underwent unilateral ureteral ligation but with verapamil given on day 0 and day 7 respectively. Apoptosis to the renal tubles were assessed after nephrectomy on day 14 using immunohistochemistry by counting the number cell deaths/high power fiels (hpf). The groups that received varapamil showed significantly less apoptosis compared to those without verapamil (2,73 vs 12,46 cell death/hpf; p0,05), although both groups still showed more cell deaths compared to group 1 (0,38 cell deaths/hpf). Verapamil appears to significantly decrease apoptosis during total unilateral ureteral obstruction. However; it cannot replace the benefit of relieving total obstruction

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Detail Information

Series Title

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Call Number

Jurnal Urologi Indonesia;17(1)2010:9-16

Publisher

Surabaya : Ikatan Ahli Urologi Indonesia., 2010

Collation

7p.

Language

English

ISBN/ISSN

0853-4438

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

kidney failure, acute
APOPTOSIS
VERAPAMIL

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