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Pengaruh Kubebin, Senyawa Lignan Piper cubeba L.f. terhadap Pelepasan Histamin dari RPMCs (The Effects of Cubebin, a Lignan from Piper Cubeba L.f. on Histamine Release from RPMCs)

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Abstract: Cubebin is a lignan isolated from Indonesian plant Piper cubeba L.f fruits. Cubebin has been found to strongly inhibit contraction of isolated-trachea of guinea pig induced by histamine or metachoJine. In the present study, the effect of cubebin was investigated on histamine release from rat peritoneal mast cells (RPMCs), a connective tissue mast cell. Compound 48/80 (G Protein activator), thapsigargin (SERCA inhibitor), ionomycin (calcium ionophore), and PMA (PKC activator) were used as inducers for histamine release from connective tissue mast cell. Histamine released in the medium was measured by HPLC-ftuorometry. The results showed that cubebin at the concentration of 30 and 100 ~M inhibited the histamine release from RPM Cs induced by thapsigargin by 12.86 ± 1.84 % and 40.38 ± 1.93 %, respectively. In addition, there was a partial inhibition seen in respond to ionomycin, with no effects towards compound 48/80 or PMA. These data indicate that cubebin inhibited the histamine release from connective mast cells, and might involve in the activation of sarco/endoplasmic reticulum Ca2+ ATPase.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Jurnal Ilmu Kefarmasian Indonesia; 8(2)2010:125-13

Penerbit

Jakarta : Fakultas Farmasi Unifersitas Pancasila., 2010

Deskripsi Fisik

5p.

Bahasa

ISBN/ISSN

1693-1831

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

PIPER
HISTOMINE RELEASE

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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