Abstract: Cubebin is a lignan isolated from Indonesian plant Piper cubeba L.f fruits. Cubebin has been found to strongly inhibit contraction of isolated-trachea of guinea pig induced by histamine or metachoJine. In the present study, the effect of cubebin was investigated on histamine release from rat peritoneal mast cells (RPMCs), a connective tissue mast cell. Compound 48/80 (G Protein activa…