Econazole is an azole antifungal agent which can block the calcium release-activated calcium (CRAC) current in human leukaemic T cell line. The phenomenon is also possible to occur in mast cell such as RBL-2H3 (rat basophilic leukemia) cells, a tumor analog of mast into the cells, a tumor analog of mast cells. In the study, we investigated effect of econazole on 45 Ca 2+ uptake into the cells…
Abstract: Cubebin is a lignan isolated from Indonesian plant Piper cubeba L.f fruits. Cubebin has been found to strongly inhibit contraction of isolated-trachea of guinea pig induced by histamine or metachoJine. In the present study, the effect of cubebin was investigated on histamine release from rat peritoneal mast cells (RPMCs), a connective tissue mast cell. Compound 48/80 (G Protein activa…
Gamavuton-0 (GVT-0), also nemed as 1,5-bis(4’hydroxy—3-methoxyphenyl)-1-4-pentadiene-3 0ne is a 1,5-diphenyl-1-4-pentadiene-3 one analog of curcumin by modifying the center site of curcumin leading to 1,4-pentadiene-3-ones to maintain the hydroxy moiety at aromatic rings which are responsible for its biological activities. Curcumin has been reported to have potrnt anticarcinogenic effects. …