ABSTRACT Hiperthyroid is execcesive thyroid function which increased thyroid hormone that suppressed TSH. Majoretiologies of hyperthyroidism (60%-80%) caused by Graves disease. Graves disease occurs in up to 2% women 20-40 years old. Some of the genes implicated in this pathogenesis may encode thyroid stimulating hormones receptors (TSHR). The TSHR gene is located on chromosome 14q31, an area …
Background:H5N1 Avian Influenza virus is expected to continue to mutate, potentially increasing the capacity to jump the species barrier, and can be easily transmitted between humans. This study aimed to analyze the genetic dynamics of the NS1 gene and to recognize markers of virulence in VAI H5N1 NS1 gene sequences from Balinese poultry. Methods:The method used was isolation of RNA, NS1 gen…
Pathogenesis a/infection ofH5NI virus involves hyperinduction a/pro inflammatory cytokines which causes the cytokine storm. Although mu/tigenic, NSJ gene can contribute to the level a/virulence and or cytokine resistance. In this study, the NS1 gene fragment of H5Nl isolated from chicken and muscovy duck in Central Java aljd Yogyakarta, respectively. were analyzed. Phylogenetic analyses were pe…
Polymerase Basic 2 (PB2) is the longest segment of Avianlnjluenza Virus (AIV) genome. has been known to play a role in cleavage and capping a/RNA, related with replication and transcription into 8 segments of virus genome. This study was aimed to find out the existence of amino acid change in positions 627 and 667 that Glutamate mutation into Lysine in position 627 PB2, determines the high path…