Polymerase Basic 2 (PB2) is the longest segment of Avianlnjluenza Virus (AIV) genome. has been known to play a role in cleavage and capping a/RNA, related with replication and transcription into 8 segments of virus genome. This study was aimed to find out the existence of amino acid change in positions 627 and 667 that Glutamate mutation into Lysine in position 627 PB2, determines the high path…