The research of synthesize and quantitative structure activity relationship of benzoy1 salicylic acid derivatives for analgesic activity in mice had been done by Soekardjo et al. (2009). From the fourteen compounds that had been synthesized, it has been known that 0-(3-chlorometilbenzoyl) salicylic acid had the best analgesic activity (ED50 value was 15.73% mg/kg) while the ED50 value of acetyl…
Piperacillin has antimicrobial action but it is not absorbed from gastrointestinal tract Therefore, it needs structure modification to increase its absorption while keeping its antimicrobial action. The 4-methy/piperazin¬N-carbonyl ampicillin was the product of reaction between ampicillin and 4-methylpiperazin-N-carbonyl chloride using Schotten Baumann method. The aim of this research was to c…