The research of synthesize and quantitative structure activity relationship of benzoy1 salicylic acid derivatives for analgesic activity in mice had been done by Soekardjo et al. (2009). From the fourteen compounds that had been synthesized, it has been known that 0-(3-chlorometilbenzoyl) salicylic acid had the best analgesic activity (ED50 value was 15.73% mg/kg) while the ED50 value of acetyl…