This was a comparative, 2-arm, parallel, randomized, double-blind, placebo-controlled study consisting of a 12-week treatment period aimed to evaluate the efficacy and safety of topical adapa-lene 0.1% cream as an anti-aging therapy. Each enrolled subjects were given both adapalene and place¬bo (vehicle) cream, each of which to be applied on either hand based on the randomly allocated num¬ber…
Phenomenon related to skin aging among others are wrinkles, increase in dryness of the skin, decrease in skin flexibility, elasticity and smoothness of the skin. The skin's most important role is its function as a barrier to prevent water loss, electrolyte and skin component loss, as well as to prevent the absorption on injurious substances. Therefore, keeping the correct balance of water in th…