This was a comparative, 2-arm, parallel, randomized, double-blind, placebo-controlled study consisting of a 12-week treatment period aimed to evaluate the efficacy and safety of topical adapa-lene 0.1% cream as an anti-aging therapy. Each enrolled subjects were given both adapalene and place¬bo (vehicle) cream, each of which to be applied on either hand based on the randomly allocated num¬ber…