Carbamazepine (CBZ) is an anticonvulsant widely used for epilepsy treatment.. However, it is difficult to establish suitable dosage regimens for this drug because of the variation on its pharmacokinetics profiles. A lot of evidences indicate that ethnic differences may affect pharmacokinetics and hence dosage requirements. The study was conducted to document pharmacokinetic profile of CBZ and i…
The increased percentage of patients with HIV-TB coinfection leads to inevitable interactions between rifapincin and efavirenz Efavirenz is a potent non-nucoside reverse transcripate inhibitor (NNRT) for the treatment of HIV infection. The use of this drug combination with rifampicin causes problem in determination of the optiml dosage of efavirenz when adminstered concomitanly with refapicin.E…
Drug-drug interactions can initiate undesirable or adverse effects. This could have a clinical implication and could also become serious health problems. Since a large number of drugs are introduced and marketed every year, new interactions between concomitant medications might possibly increase. The safety profile of drugs including the impacts of drug-drug interactions can be provided …