Background: The present study was aimed to explore the effects of ritonavir and primaquine combination given as a singledose or repeated-dose compared to ritonavir alone on ritonavir plasma concentration in the rats. Methods: In single-dose study, 30 male Spraque Dawley rats were randomly allocated to receive ritonavir 20 mg/kg BW or ritonavir 20 mg/kg BW + primaquine 1.2 mg/kg BW or ritonav…
Drug-drug interactions can initiate undesirable or adverse effects. This could have a clinical implication and could also become serious health problems. Since a large number of drugs are introduced and marketed every year, new interactions between concomitant medications might possibly increase. The safety profile of drugs including the impacts of drug-drug interactions can be provided …