Primaquine decreased plasma concentration of ritonavir: single- and repeated-…

Background: The present study was aimed to explore the effects of ritonavir and primaquine combination given as a singledose or repeated-dose compared to ritonavir alone on ritonavir plasma concentration in the rats. Methods: In single-dose study, 30 male Spraque Dawley rats were randomly allocated to receive ritonavir 20 mg/kg BW or ritonavir 20 mg/kg BW + primaquine 1.2 mg/kg BW or ritonav…

Telmisartan inhibits the progression of cardiomyopathy in daunorubicin treate…

Background: Anthracyclines have been reported to induce cardiotoxicity through mechanisms involving formation of advanced glycation end-products (AGEs), including pentosidine and Nє-(carboxymethyl) lysine (CML). We investigated the potential utility of telmisartan (TML), an angiotensin II receptor antagonists (ARB) on anthracycline-induced cardiotoxicity. Methods: Three groups of Sprague…

A Meta-analysis on Treatment Effects of Thiazolidinediones for Type 2 Diabete…

Aim: to assess the effects of thiazolidinediones (pioglitazone and rosiglitazone) in the treatment of T2DM in Asian population. Methods: randomized controlled trials of T2DM patients in Asian population that compared pioglitazone or rosiglitazone with other treatments for more than 3 months and reported HbA1c data were included. Analyses for all outcomes were calculated using random effect m…

Primaquine decreased plasma concentration of ritonavir: single- and repeated-…

Background: The present study was aimed to explore the effects of ritonavir and primaquine combination given as a singledose or repeated-dose compared to ritonavir alone on ritonavir plasma concentration in the rats. Methods: In single-dose study, 30 male Spraque Dawley rats were randomly allocated to receive ritonavir 20 mg/kg BW or ritonavir 20 mg/kg BW + primaquine 1.2 mg/kg BW or ritonav…

Incretin-Based Therapies for Type 2 Diabetes in Asian Patients: Analysis of C…

Aim To review the efficacy and safety data on incretin-based therapies currently available (exenatide, liraglutide, sitagliptin, vildagliptin) for the treatment of type 2 diabetes mellitus in Asian population. Methods We conducted Medline search of all relevant randomized clinical trials of incretin-based therapies for type 2 diabetes mellitus in Asian populaticns. Data pertinent to the effica…

Pharmacological Review of Thizolidinediones for in Type 2 Diabetes Melitus

Edition

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ISBN/ISSN

0125-913X

Collation

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Series Title

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Call Number

Cermin Dunia Kedokteran:37(3):174-180

The Pharmacology of Muscle Relaxant (Farmakologi Obat-obat Pelemas Otot)

Muscle relaxants have two ways in their working. First, the muscle relaxant which worked in peripher (e.g.: dantrolen), and second, the muscle relaxant which worked in central (e.g.: diazepam, baclofen, carisoprodole, and Tizamidine). This article reviewed about tizanidine as muscle relaxant which worked centrally. This drugs especially worked in medulla spinalis. It was derived to imidazoline …