Apoptosis is an important target on anticancer mechanism. The purpose of this research is to investigate apoptosis induction of Selaginella plana Hieron active fractions on T47D cells. Absolute ethanol was used to extract Selaginella /Diana powders. Ethanolic extract was dilluted by methanol:water (4:1) and then fractionated by hexane (S Hex), methylene chloride (S_MTC), ethyl acetate (S_EA), a…
Background: This research is aimed to prove the role of Mahkota Dewa polyphenol in the up-regulation Bax and down-regulation in strain Balblc mice which inducted with benzo(a)pyrene (BaP). Method: Post test control group design with 30 strain Balblc mice sample, aged 1-2 weeks, weighed 20-30 grams, healthy mice condition. All mice inducted with BaP and then randomized into 2 groups, which wer…
Carcinogenesis process was a ffected by decrease in apoptotic activities marked by low Caspase- 3 expression. Soybean (Glycine max) tempe is a widely consumed permented food. Isoflavon content of tempe showed proapoptotic effect on cancer. The aim of this study is to know the effect of soybean tempe extract on Caspase -3 expression of C3H mice (Musmusculus) breast carcinogenesis model. This exp…
Exessive hepatocyte apoptosis induced by bile acid accumulation occured in severe obstructive jaundice, and impair the liver secretion function. The objective of this study is to determine whether the inhibition of bile acid accumulation through bile duct decompression affect the excessive hepatocyte apoptosis and caused improvement the liver secretion function on human model. In this study we …
Corpus luteum is a transient endocrine gland and its presence plays pivotal role in ovulation process, implantation, and luteinization.The regression of corpus luteum or luteolysis is actually ne eded for next cycle survival and playing a role in roviding new follicles. Luteal regression represents a broad definition of the rocess of demise of the corpus luteum that is capable of accommodatin…
Apoptosis is known to maintenance of tissue homeostasis and elimination of cancer cells. Whithout programed cell death, cell proliferation would lack on important component of control of oncogenic process. Apoptosis is caused by various inducers such as chemival compound and toxin. Aflatoxin B1 is a potent toxin. In the liver, it undergoes biotransformation which produces reactive oxigen specie…
Obstruction of the urinary tract has marked effects on renal blood flow glomerular filtration rate (GFR). And tubular function. Ureteral obstruction results in an injury response that can progress to irreversible renal fibrosisand tubular damage by apoptosis. Forty five rabbits aged 13-17 weeks with body weights of 1250-1750 grams were devided into 4 groups. Group 1 underwent a sham operation a…