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Ultraviolet A (UVA)irradiation on human skin can generate free radical and stimulate matrix metalloproteinase produktion resultingin collagen degradation and transforming growth factor beta (TGF-β) inhibition. It causes synthesis collagen inhibition and induces cell death. Α-Lipoic acid (ALA) is an universal antioxidant and a powerful scavenger of free radicals. In this study we investigated …
A new spectrometrical methodwas developmend to determine a marker for liver damage. The aims of this study was to investiagte the pattern of cellular interaction in EDTA blood spectrometrically in rats that induced by carbon tetrachloride (CC14), Eight of white male rats (Rattus norvegicus L), aged of 2 months with body weight of 160-210g were divided into two groups with 4 rats in each group. …
Dental caries is a major problem of dental health in Indonesia. Streptococcus mutans is a bacteria that can cause caries. In the recent time, the agents used to eliminate the caries is less efective due to S. Mutans resistance to those alternative agents dental caries is needed. Red betel (piper crocatum Ruiz & Pav) is a promising natural material to treat dental caries. The P. Croatum Ruiz & P…
Drug resistance is one of the global problems, particularly in communicable diseases control including Indonesian malaria elimination program. Since 2004, Artesunate-Amodiaquine (AS+AQ), an Artemisinin based Combination Therapy (ACT), has been used in Indonesia as recommended by the WHO for treatment of acute uncomplicated malaria, replacing of chloroquine resistant antimalarial. Since then, im…
Malaria is still a public health problem in Indonesia. The clinical manifestation of malaria is varied, and many factors may influence its clinical manifestation. Despite the species of malaria, density of parasitemia is known related to the severity or malignancy of malaria. It is worth to analyse the clinical and laboratory data of malaria cases in monitoring dihydroartemisinin-piperaquine (D…
Background. Since 2004, Malaria Program in Indonesia has used Artemisinin Combination Therapy (ACT) to replace the chloroquine resistance. The recommended ACT is Artesunate dan Amodiaquine (AAQ) combination for uncomplicated falciparum malaria. To relieve side effects and clinical complaints of malaria , health workers usually gave symptomatic and other drugs in addition to antimalarial drugs.…
Since 2008, Dihydroartemisinin-Piperaquine (DHP) has been used as the first-line drug for treatment of falciparum malaria in Papua, which gradually will also be used in other endemic areas. The objective of the study was to determine the safety and efficacy of DHP. Patients with uncomplicated malaria due to Plasmodium falciparum were enrolled and treated with supervised DHP (arterakin ®, no. …
The development of DHF patient usually assessed base on clinical condition, platelet count and haematocrit value as the DSS indicators. While leukocyte count is irrespective though leucopenia is common in viral infection. Therefore, further analysis was run to determine whether leucopenia could be as a predictor of DSS This study was a retrospective study with a case control (1:2) design usi…