Dental caries is a major problem of dental health in Indonesia. Streptococcus mutans is a bacteria that can cause caries. In the recent time, the agents used to eliminate the caries is less efective due to S. Mutans resistance to those alternative agents dental caries is needed. Red betel (piper crocatum Ruiz & Pav) is a promising natural material to treat dental caries. The P. Croatum Ruiz & P…