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Parathyroid carcinoma (PTCA) is a rare neoplasm that accounts for less than 1 % of primary hyperparathyroidism cases. Several clinical and biochemical features can directing to PTCA, but accurate pre and intraoperative diagnosis are still difficult. This study presents a case of PTCA that diagnosed postoperatively with a discussion of microscopic feature. The surgical exploration revealed an en…
Background: Previous study showed leprosy patients have low zinc status. Yet the status of zinc in close-contact, which indicated by IgM anti-PGL1 level, have not determined. The aim of the study was to determine the association of zinc plasma and IgM anti-PGL-1 levels among close contact of leprosy patients in Indonesia. Methods: This was an observational study. Subjects were 186 close-conta…
Background: Natural resistance associated macrophage protein (NRAMP) is a proton/ divalent cation transporter which play a roll in iron trafficking in the phagosomes. Variations in NRAMP1 gene have been reported to be associated with susceptibility to tuberculosis (TB) because Mycobacterium tuberculosis (MTb), the causative agent of TB, compete with its host to uptake iron for its metabolism. T…
Results: The post-operative IL-6 serum level showed a downward trend compared to pre-operative value (mean decrease: -190.61 pg/mL). The post-operative IL-6 level was significantly associated with GCS 7 days post-operation (p = 0.006), with OR 24. The post-operative IL-6 serum level was significantly associated with GOS 3 months post-trauma (p = 0.016) with OR 11.6. The post-operative uric acid…
Background: This study was done to determine the effect of root extract of Acalypha indica Linn (akar kucing) in protecting neuron viability ofthe rat hippocampus on tissue culture in hypoxic condition. Methods: This is an experimental study of in vitro prirnary cell culture of hippocampus of Sprague Dowley aduh rat. The cultures were group into control (C) and exposure to root extract of Aca…
Background: Exercise increases the need for oxygen to generateATP through oxidative phosphorylation. If the high energy demand during exercise is not balanced by sufficient oxygen supply, hypoxia occurs in skeletal muscle tissue leading to upregulation ofhypoxia inducible factor-1α (RIF-1α). The activity of RIF-1α increases the expression ofvarious genes in order to reduce the metabolic depe…
Background: Cobalt chloride can be used as an agent to stabilize hypoxia inducible factor-1α (HIF-1α) and to imitate hypoxia without low levels of oxygen inside the body. We intended to Investigate if there was any regulation of renin expression by HIF -1α. Therefore, we conducted several studies to elarify this possibility starting with the induction of hypoxic mimicry in rats by intra-per…
Background: The goal of this study was to analyze the correlation of oxidative stress in human glioma cells with tumor grade in order to explore the role of oxidative stress as a marker in determining the tumor progression. Methods: Samples were 21 brain tumors and 5 normal brain tissues from glioma patients. Oxidative stress was analyzed by measuring malondialdehyde (MDA), carbonyl and 8-hyd…
At the moment people tend not to have time for exercise because of the busyness and all-round modern lifestyles, such as using a motor vehicle more often compared to walking or cycling, using the elevator in the building. As well as the majority of cardiologists who treat patients heart attacks with jogging under the supervision can reduce heart attack, the heart make vessels colIaterais thus t…
Endometriosis is a term used to describe the presence of functioning endometrial glands and stroma outside the uterine cavity and musculature. Endometriosis is estimated to affect 5-10% women of reproductive age but there are some cases reported as endometriosis in postmenopausal women. Endometriosis is classified as pelvic and extrapelvic endo-metriosis. The majority of extrapelvic endometrios…