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Mirabilis jalapa L. contains basic (MJ30) and acidic (MJC) Ribosome-inactivating proteins (RIPs). Further purification of MJC has been found two RIPs, MJCO.3 and MJCO,5' This study is aimed to prove the cytotoxic selectivity of MJCO.3and MJCO.5against many cancer cell-lines and normal cell line. The two RIPs, MJCo,jend MJC05 were tested their cytotoxic effect on 8 human cancer cell lines and no…
The aim of this study was to evaluate the cytotoxicity of several tooth whitening material, carbamide peroxide 10%, 15%, 20% and hydrogen peroxide 38% toward BHK-21 cell using MTT assay. Each well of microplates which used for the test were aliquotted BHK-21 cell suspension, after that the test solution were added to eight well each group, respectively. Microplates were incubated at 37⁰C in 5…
Propolis is resin with complex chemplex chemical composition that collected by honeybees from various plants. It has been known that propolis has several biological properties, such as antimicrobial, anti-inflammatory,antioxidant and immunomodulatory activities. The aim of this study is to evaluate the proporlis’s cytotoxic and antiproliferative activity in vitro on hela cell line. These cell…
In the last few years there are tendency for cancer study to develop in discovery of new chemical entity (NCE) for new drugs. The needed of NCE based on reality that cancer can be used at one therapy and be implemented as a solution to inhibit a resistant level and very useful in recovery time. Natural products are the most important sources of INCE and could be used from plants. Animals or min…
Gamavuton-0 (GVT-0), also nemed as 1,5-bis(4’hydroxy—3-methoxyphenyl)-1-4-pentadiene-3 0ne is a 1,5-diphenyl-1-4-pentadiene-3 one analog of curcumin by modifying the center site of curcumin leading to 1,4-pentadiene-3-ones to maintain the hydroxy moiety at aromatic rings which are responsible for its biological activities. Curcumin has been reported to have potrnt anticarcinogenic effects. …
Eurycomanoms is a cytotoxic ingredient found in Eurycoma longifolia jack .Previous studies have noted its activity against many epithellal cell lines. In this study, eurycomanone had abvious cytotoxic effect on Hela cell by methylene blue staining assays. After HeLa were treated with surycomanone, typical morphological changes, including cytoplasm shrinkage and decrease of cell volume were obse…