More than 40% of the world's population who live in tropical and subtropical regions at risk for dengue infection. Specific and effective antiviral therapies to treat dengue infection has not been found yet. Many researches proved that curcumin has preventive activity againts viruses, such as vasicular stomatis (VSV), HSV 1 and 2, parainfluenza-3, reovirus-1, feline corona virus, feline herpes …
Dengue virus infects 50 to 100 million people every year, however, specific treatment or effective antiviral drugs to treat viral infections has not been found yet. Curcumin known has perform the inhibition of ubiquitin-proteasome system that causes a decrease of Japanese encephalitis, one kind of flavivirus. Structural modifications was known to increase the biological activity of curcumin. P…
Gamavuton-0 (GVT-0), also nemed as 1,5-bis(4’hydroxy—3-methoxyphenyl)-1-4-pentadiene-3 0ne is a 1,5-diphenyl-1-4-pentadiene-3 one analog of curcumin by modifying the center site of curcumin leading to 1,4-pentadiene-3-ones to maintain the hydroxy moiety at aromatic rings which are responsible for its biological activities. Curcumin has been reported to have potrnt anticarcinogenic effects. …
PGV-1 or 2,5-bis(4’-hydroxy-3,5’-dimethylbenzylidene) cyclopentanone and RGV-2 or 2,5-bis(4’-hydroxy-3’-5’-diethybenzylidene)cyclopentanone are tro benzylidene cyclopentanone analogues of curcumin. In or study, we ivestiggeted the effects of these compounds on the β-hexoaminidase enzyme relese from mast cell culture (RBL-2H3 cell line,). Thapsigargin and lonomycin were used as intrac…