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The Monitoring of Cephalexin in Blood, Urine and Feces of Rats Following Administration of its Derivative N-benzoyl-cephalexin (Pemantauan Sefaleksin dalam Darah, Urin dan Feses Tikus setelah Pemberian N-benzoil)

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An investigation has been performed to monitor cephalexin in blood, urine and feces of rats following administration of its derivative N-benzoyl-cephalexin. Female Wistar rats were randomly divided into two groups of six animals. To the first group N-benzoyl cephalexin (equivalent to cephalexin 25 mg/kg) was given orally in 10 percent PVP suspension to the fasted rats. Blood samples (200 ul) were taken periodically at 0, 2, 10, 30, 40, 50, 60, 90, 120, 150 and 180 minutes after drug administration from the lateral tail vein to analyse the unchanged cephalexin content fluorometrically (excitation 345 nm and emission 425 nm). The second group of the fasted animals were received the same treatment, after which urine and feces were collected during 0-30 hours for the analysis of unchanged cephalexin. The results have shown that within 0-6 and 6-12 hours, the respective amounts of urinary excretion of cephalexin were 4.85 plus/minus 2.79 ug and 5.58 plus/minus 2.99 ug, with total amount excreted during 0-30 hours of 23.52 plus/minus 11.86 ug. There was no N-benzoyl moiety was found in the urine after TLC, but only cephalexin, indicating that all the absorbed derivative was biotransformed into its parent compound. The amount of cephalexin found in feces for 30 hours collection was 201.4 plus/minus 58.3 ug, or 5.90 percent of the cephalexin dose.

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Majalah Farmasi Indonesia,6(3)1995:90-4

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: ., 1995

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cephalexin

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