The present work was aimed to compare the pharmacokinetic profiles of sulfanilamide and its derivative sulfamethizole in the rat. Female Wistar rats were divided into two equal groups randomly, and each was injected with sulfanilamide or sulfamethizole (40 mg/kg: ip). The sulfonamide blood concentrations were monitored colorimetrically employing a Bratton-Marshall assay method. The result showe…
An investigation has been performed to monitor cephalexin in blood, urine and feces of rats following administration of its derivative N-benzoyl-cephalexin. Female Wistar rats were randomly divided into two groups of six animals. To the first group N-benzoyl cephalexin (equivalent to cephalexin 25 mg/kg) was given orally in 10 percent PVP suspension to the fasted rats. Blood samples (200 ul) we…