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Efficacy of Artemisinin-Naphtoquine and Dihydroartemisinin-Piperaquine for Uncomplicated Malaria Patient at Primary Health Care

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Our previous study of single dose artemisinin-naphthoquine (ANT) in adult majority male patients showed it as a safe, tolerable, and very effective treatment for uncomplicated malaria. More data is required to verify safety and efficacy from other age groups before this new drug could be widely used in Primary Health Care (PHC)s in Indonesia.

For this study, we modified the 2009 WHO guidelines for clinical trials. This quasi-experimental study compared two parallel groups, subjects given ANT at 5 PHCs with inpatient facilities, and subjects given the control drug dihydroartemisinin-piperaquine (DHP) administered to subjects at 5 PHCs without inpatient facilities.

Of a total 182 recruited subjects, 168 malaria cases could be analyzed. There were 71 cases in the ANT group and 97 cases in the DHP group. The characteristics of subjects receiving ANT and DHP at baseline were similar except the proportion of axillary temperature ≥37.50C, and proportion of anaemic subjects (Hb

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Detail Information

Series Title

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Call Number

Health Science Journal of Indonesia, 5(2): 100-105

Publisher

Jakarta : Sekretariat Balitbangkes., 2014

Collation

6p

Language

ISBN/ISSN

2087-7021

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

malaria
PRIMARY HEALTH CARE
PHARMACEUTICAL PREPARATIONS

Specific Detail Info

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