Perbandingan Efektifitas Dosis Sekali Minum Artemisinin-Naftokuin dengan Dihidroartemisinin-Piperakuin pada Pengobatan Pasien Dewasa Malaria Falsiparum tanpa Komplikasi | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Perbandingan Efektifitas Dosis Sekali Minum Artemisinin-Naftokuin dengan Dihidroartemisinin-Piperakuin pada Pengobatan Pasien Dewasa Malaria Falsiparum tanpa Komplikasi

Hadjar Siswantoro - Personal Name; Armedy Ronny Hasugian - Personal Name; Telly Purnamasari - Personal Name; Sri Laning - Personal Name; Lidwina Yanuar - Personal Name; Tersila Dedang - Personal Name; Emiliana Tjitra - Personal Name;

A practical and simple Artemisinin based combination therapy (ACT) with good compliance in adult patients for all malaria species has been shown in the first article: “Efficacy and Safety of Artemisininnaphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia”. It is worth to add data safety and efficacy of single dose artemisininnaphthoquine (ANT) compared with dihydroartemisinin-piperaquine (DHP) in adult patients with P.falciparum malaria.

The aims of this study is to compare safety and efficacy of ANT with DHP in adult patients with uncomplicated P.falciparum malaria. this study is a clinical trial phase III, randomized, open-label using unsealed envelopes, using WHO protocol to measure efficacy of antimalaria drug with 42 days of follow-up.

The results show the efficacy of ANT and DHP at day 42 was 100% (74/74) and 97.1% (66/68), respectively with 2.9% (2/68) late treatment of failure for DHP. Adverse event was 2.5% cough after ANT treatment, and 1.4% cough after DHP treatment. The conclusion is that single dose of ANT is safe and very effective similar with DHP single daily dose for three days for treatment adult patients with uncomplicated P.falciparum malaria.

Keywords : malaria, dihydroartemisinin-piperaquine, artemisinin-naphthoquine, Plasmodium falciparum, Indonesia.

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Location name is not set Media Litbangkes, 24 (3) : 129-136

A0004529

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Series Title: -
Call Number: Media Litbangkes, 24 (3) : 129-136
Publisher: Jakarta : Puslitbang Ekologi Kesehatan,Badan Litbangkes., 2014
Collation: 8p
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ISBN/ISSN: 0853-9987
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Subject(s): malaria
plasmodium falciparum
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