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Optimal time aof administration of fentanyl in reducing hemodynamic response in endotracheal intubation

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ABSTRACT

Laryngoscopy and endotracheal intubations are frequently conducted in general anesthesia. However, it can stimulate symphatic and sympatoadrenal activities. Several non and pharmacological interventions have been used to reduce the symphatic stimulation. Fentanyl is one of the opioid drugs that frequently used to decrease the cardiovascular responses after the intubations. In order to obtain an optimal effect, fentanyl should be administered in appropriate time.

This study was conducted to compare the time of fentanyl administration at 2, 5 and 7 minutes before endotracheal intubation to reduce hemodynamic responses. This was an obervational study with a prospective cohort design on patients who were going to undergo elective sugical using general anesthesia followed laryngoscopy intubation in Dr Sardjito General Hospital and met the inclusion and exclusion criteria.

The patients were then divided into 3 groups i.e patients who received lentanyl 1.5 µg/kg body weight (BW) intravenously (IV) 2 minutes (Group A), 5 minutes (Group B) and 7 minutes (Group C) before laryngoscopy intubations. The hemodynmic responses including sistolic and diastolic blood pressure (SBP and DBP), mean arterial pressure (MAP), heart rate CHM and rate pressure product (RPM were monitored and recorded every 1 minute during 7 minutes period.

The result showed that fentanyl administration 5 minutes before laryngeal intubation was more effective in the decrease hemodynamic response that those 2 and 7 minutes. Significantly different in SBP in 2, 3, 4 and 7 minutes observations was observed (p

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Journal of the Medical Sciences, 46 (2) : 78-87

Penerbit

Yogyakarta : FK UGM., 2014

Deskripsi Fisik

10p

Bahasa

ISBN/ISSN

0126-1312

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

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