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Ulasan Sistematik: Marka Molekular Penanda Patogenitas dan Sebaran Inang Pada Virus Avian Influenza H5N1

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The epidemic arising out of H5N1 virus infection causes death case and material loss. Mutation of H5N1 virus that signify the increase of pathogenicity and change of dispersal of host response can be used to reference for early warning system of epidemic caused of avian influenza virus.

The objective of this research is to obtain information related to molecular markers of pathogenicity of avian influenza. Reference searching is use to collect information about molecular markers related to pathogenicity. The keywords used on this study are: Avian influenza, H5N1, mutation, Pathogenicity, HA, NA, PB, PA, and NS.

Thirty three research papers, 4 reviews and 1 scientific seminar are used on this research. The HA, NA and NS genes was reported to be an important gene that have molecular marker related to increase ofpathogenicity. Whereas HA, PB1, PB2 and PA genes was related to the adaptive ability and the dispersal of host of avian influenza virus. There is 30 amino acid that sign as molecular markers of pathogenicity of avian influenza H5N1. Mutation on 30 molecular markers of HA, NA, PB and NS genes can be used as predictor to anticipate mutation orientation of avian influenza virus to become highly pathogenic and host alteration.Thereby, virus mutation to become highly pathogenic can be anticipated early.

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Series Title

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Call Number

Jurnal Biotek Mediciana Indonesia, 2(1)2013: 9-18

Publisher

Jakarta : Pusat Biomedis dan Teknologi Dasar Kesehatan., 2013

Collation

Jurnal Biotek Mediciana Indonesia

Language

ISBN/ISSN

2301-5810

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

INFLUENZA A VIRUS, H5N1 SUBTYPE

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