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Combination of three species of Zingiberaceae prevents doxorubicin-induced hepatotoxicity (Kombinasi tiga spesies Zingiberacea mencegah hepatotoksitas yang diinduksi doksorubisin)

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BACKGROUND
Doxorubicin as an ant icancer drug has hepatotoxic side effects. Curcuma xanthorrhiza. Curcuma longa and Zingiber officinale are commnonly used as herbals in lndonesia and around the world. Several compounds in these plants have antiox idant activities and are known to exhibit protection against doxorubicin-induced toxicities. This study aimed to observe the hepatoprotective effect of a combination of C xanthorriza. C. longa. and Z. ofiicinale extract on doxorubicin-induced hepatotoxicity in rats.

METHODS
A total of 28 Wistar male rats were divide d into four groups: 1) control group (0.9% NaCI): 2) doxorubicin 5 mg/kg intraperitoneally (ip) four times in 14 days (days 1.5,9. 13); 3) doxorubicin +- combination of C xonthorriza, C. longa, and Z. officinale (temulawak. kunyit, and jahe merah, designated as Tekuja) 250 mgkg/day orally for 14 days: and 4) doxorubicin+ Tekuja extract 500 mg/kg/day orally for 14 days, Measurements of parameters based on liver histopathology and the parameters of serum alanine amino transferase (ALT) and aspartate amino tranferase (AST).

RESULTS
Doxorubicin caused significant elevation in serum ALT and AST enzymes after 14 days of treatment. Rats treated with doxorubicin + Tekuja extract 250 mg/kg/ day showed no histological changes, but had dccreased levels of ALT and AST.

CONCLUSION
This study indicates that the combination of C. xanthorriza. C longa. and Z olficinale has a prot cetive effect in rats against Iiver damage induced by doxorubicin

Key words: Doxorubicin, Curcuma xanthorriza, Curcumia longa, Zingiber olfficinale, hepatotoxicity, rats

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

UNIVERSA MEDICINA, 32 (1) 2013: 11-19

Penerbit

Jakarta : Puslitbang Farmasi, Badan Litbang Kesehatan., 2013

Deskripsi Fisik

9p

Bahasa

ISBN/ISSN

1907-3062

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Tipe Media

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