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Caspase-3 can not be Used to Predict the Response to Neoadjuvant Chemo therapy Regiment PVB in Cervical Cancer Stage IB-IIA Kaspase-3 tidak dapat DigunakansebagaiPrediktorKeberhasilan Pemberian Kemoterapi Neoajuvan Regimen PVB pada Kanker Serviks Stadium IB-11A

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Abstract
Objectives: To determine the factors that may be used as the prog¬nostic parameter for the therapeutic efficacy of neoadjuvant chemo¬therapy, which can be used to revising the management of early stage cervical cancer patients with large lesions.

Methods: This was a retrospective cohort study. The study was con¬ducted in the Dr. Cipto Mangunkusumo Hospital, Faculty of Medi¬cine, University of Indonesia. The subjects were 15 cervical cancer stage IB2 and IIA patients with lesions' size of > 4 cm, who would be treated with neoadjuvant chemotherapy, consisted of cisplatin 50 mg/m2, vincristine 2 mg/m2 and bleomycin 15 mg regiment. The pa¬tients' response would be evaluated after completing 3 series of che¬motherapy. Data was retrieved from medical records and cervical bi¬opsy paraffin blocks and examined histopathologically using IHC staining to see expression of caspase-3 with histoscore assessment score. Data was analyzed by univariate, bivariate analysis.

Results: Response to PVB neoadjuvant chemotherapy was found in 5 out of 15 patients. None of the clinicopathology variables can be used to predict response to therapy. Expression of caspase-3 as a marker of apoptosis, can not predict the response of the therapy be¬fore administrating neoadjuvant chemotherapy either. There is a significant difference between the levels of caspase-3 in epidermoid carcinoma with adenocarcinoma, with p value of 0.02 (RR 6;95% CI 1.69-21.26).
Conclusion: Clinicopathologic factors and the expression of caspase-3 before getting chemotherapy neoadjuvant can not predict the succeed of the therapy.
[Indones J Obstet Gynecol 2013; 1-3: 156-60]
Keywords: caspase -3, clinicopathologic, early-stage cervical cancer lession in large, neoadjuvant chemotherapy response to therapy

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Indonesian Journal of Obstetrict and Gynecology, 1

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Jakarta : Indonesian Society of Obstetetrict and Gynecology., 2013

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5p

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2338-6401

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