Abstract Objectives: To determine the factors that may be used as the prog¬nostic parameter for the therapeutic efficacy of neoadjuvant chemo¬therapy, which can be used to revising the management of early stage cervical cancer patients with large lesions. Methods: This was a retrospective cohort study. The study was con¬ducted in the Dr. Cipto Mangunkusumo Hospital, Faculty of Medi¬cine…
Abstract Objective: To understand the molecular profile by identifying the mutation of KRAS and BRAF in borderline type ovarian tumor. Method: In the study, we examined paraffin tissue sample from De¬partment of Pathology Anatomy, University of Indonesia/Dr. Cipto Mangunkususmo Hospital, Jakarta, that was diagnosed as borderline epithelial ovarian tumor. Seventeen samples were taken to San…
Objective: To find out the diagnostic value of CA125 and HE4 as a tumor marker, and also RM1 and ROMA as a malignancy predictor in patients with ovarian tumors. Methods: This study was a diagnostic study using cross-sectional design.This study was performed in Jakarta from November 2010 to May 2011. One hundred and twenty eight serum samples of patients diagnosed with ovarian tumors were col…
Abstract Objective: To assess whether VEGF-C expression can predict the response to neoadjuvant chemotherapy and pelvic lymphnode metastases in bulky cevical cancer.Methods: Seventeen cervical cancer stage IB2 and IIA2 cases during the period of July 2009 until June 2010 were collected consecutively and given neoadjuvant chemotherapy (NAC) PVB prior radical surgery. Response to treatment was ev…
Abstract Objective: To evaluate and determine the toxicity and outcomes in patient receiving radiation (RT) alone versus concurrent chemoradiation (CRT) using cisplatin for locoregional advanced cervical cancer in Dr. Cipto Mangunkusumo Hospital (RSCM). Methods: Simple randomized single-blind clinical study, done during the period of November 2010-April 2011, in 32 patients with locoregional ad…
Background: Obstructive sleep apnea has been known as one of risk factor for coronary artery disease (CAD). The aim ofthis study is to examine the relation of oxygen desaturation index (ODI) due to OSA and CAD. Methods: This study included 74 OSA men who were diagnosis of CAD by previous medical examination using treadmill and CT angiography and cardiac catheterization. Polysomnography was pe…
Introduction: Coronary calcification is a subclinical condition that may cause coronary artery disease (CAD). The main issue of obstructive sleep apnea (OSA) is the intermitten hypoxemia which is an important stimulus to increase morbidity and mortality in cardiovascular disease. In this study we investigate the male OSA patients with abnormal calcium score (Ca score) to predict CAD. Methods:…
Objective: The purpose of this study was to determine the cor-relation between decreased E-Cadherin and Bf-integrin expression in resectable endometrial cancer with the depth of myometrial inva¬sion and pelvic lymph node metastasis. Method: This was a cross sectional study, we used immunohis-tochemistry examination on E-Cadherin and Bt-integrin expression in resectable endometrial cancer pati…
To distinguish the expression of NF-kB and COX-2 between young and older group of sporadic colorectetal cancer patients. This was a comparative study between sporadic CRC patients aged 40 years or younger and patients aged 60 years or more. Expression of NF-kB and COX-2 were assessed by immunohistochemical method using rabbit polyclonal antibodies against human p65 NF-kB and COX-2 proteins. The…