Sasaran Aksi Pentagamavunon-O pada Steroidogenesis Sc! Luteal Melalui Pengukuran Fosforilasi (The Action Target of Pentagamavunon-O on the Luteal Cell Steroidogenesis Through Phosphorylation Measurement of Extracellular Signal Regulated Kinase).-- Journal of The Indonesia Medical Association, 63 (2) 2013 : 52-57 | Perpustakaan dan Galeri Kebijakan Kesehatan

Pencarian berdasarkan :

SEMUA Pengarang Subjek ISBN/ISSN Pencarian Spesifik

Pencarian terakhir:

Text

Sasaran Aksi Pentagamavunon-O pada Steroidogenesis Sc! Luteal Melalui Pengukuran Fosforilasi (The Action Target of Pentagamavunon-O on the Luteal Cell Steroidogenesis Through Phosphorylation Measurement of Extracellular Signal Regulated Kinase).-- Journal of The Indonesia Medical Association, 63 (2) 2013 : 52-57

Djaswadi Dasuki - Nama Orang; Endang Purwaningsih - Nama Orang; Sri Kadarsih Soejono - Nama Orang; Edy Meiyanto - Nama Orang;

Introduction: Pentagamayunon-0 (PG V-0) compound, a curcurnin analog, can inhibit steroido¬genesis of luteal cell culture by inhibiting the production ofprogesterone. The action site of PG V¬0 on steroidogenesis of luteal cells is still unknown. The objective of this study is to analyze the effect of PGV-0 on the Extracellular Signal Regulated Kinase (ERK) phosphorylation in steroido¬genesis of luteal cell culture.
Methods: This study used corpus luteum of rat Sprague Dawley strain that was induced with Pregnant Mares Serum Gonadotropine (PMSG). Pentagamavunon-0 was given shortly after the stimulation of LH and or PGF2a with or without forskoline. The phosphorylation of ERK was assessed by IHC method.
Results: The result showed that LH stimulation increased ERK phosphorylation significantly. However, PGF2a decreased ERK phosphorylation significantly. Forskoline increased ERK phosphotylation significantly but no significant effect was found with LH stimulation. PG V-0 inhibited ERK by either LH or forskoline stimulation.
Conclusion: Pentagamavunon-O/PGV-0 can inhibits signal transduction of steroidogenesis luteal cells by acting on the up stream to ERK. J Indon Med Assoc. 2013;63:52-7
Keywords: luteal cell, ERK, immunohistochemisty, forskolin

Ketersediaan

Belum memasukkan lokasi Journal of the Indonesian Medical Association (Ma

A0003843

Tersedia

Informasi Detail

Judul Seri: -
No. Panggil: Journal of the Indonesian Medical Association (Ma
Penerbit: Jakarta : Yayasan Ikatan Dokter Indonesia (IDI)., 2013
Deskripsi Fisik: 6p
Bahasa
ISBN/ISSN: 2089-1067
Klasifikasi: -
Tipe Isi: -
Tipe Media: -
Tipe Pembawa: -
Edisi: -
Subjek: LUTEA CELLS
Info Detail Spesifik: -
Pernyataan Tanggungjawab: -

Versi lain/terkait

Tidak tersedia versi lain

Lampiran Berkas

Tidak Ada Data

Komentar

Anda harus masuk sebelum memberikan komentar