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Analisa Kualitatif dan Kuantitatif Teofilin dan Metabolitnya dalam Darah Tikus yang Diinduksi Bunga Kubis (Brassica oleracea var Botrytis L.) {(Qualitative and Quantitative Analysis of Theophylline and its Metabolites in Blood of Rats Induced with Cauliflowers (Brassica oleracea var Botrytis L.)}

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Theophylline is known as bronchodilator. Changes in the composition oftheophylline metabolites indicates the changes in its metabolism as well as its bronchodilator effect and its toxicity. Cauliflower is known has activity as enzyme inducers. The amount of theophylline and its metabolites were expressed as percentage of theophylline dose in blood.
The study was aimed to examine the changes of theophylline and its metabolites composition in rats with cauliflower induction. Twenty-five rats divided into 5 groups. Group I, as acontrol. Groups II and III were given cauliflower of 100 g/kg BW, for 5 and 10 days. Groups IV and V were given 200 g/kg BW for 5 and 10 days. All groups were given asingie theophylline dose of 20 mg/kg BW. Theophylline and its metabolites were determined by HPLC method. The administration of cauliflower at 100 g/kg BW for 5 days have produced metabolites as 1,3-dimethyluric acid (83,78%), 3-methyl xanthine (15,26%), and theophyUine (0,97%); and treatment for 10 days produced metabolites as (69,03%), (29,40%), and (1,76%) respectively. Increase dose of cauliflower to 200 g/kg BW for 5 days has changed metabolites into (68,95%), (24,31%), and (0,92%) respectively; and treatment for 10 days has changed metabolites as (83,91%), (25,29%), and (1,70%). Induction of cauliflower into rats have significantly influenced the composition ofthgophylline and its metabolites in blood (p>0.05).
Keywords: Theophylline, 1,3-dimethyl uric acid, 3-methyl xanthine, rat blood, cauli flower, HPLC, Brassica oleraceae.

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Jurnal Ilmu Kefarmasian Indonesia, 10 (2) 2012 : 1

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Jakarta : Jurnal Ilmu Kefarmasian Indonesia FF Universitas Pancasila., 2012

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6p

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1693-1831

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