Efikasi dan Keamanan Dihidroartemisinin-Piperakuin (DHP) pada Penderita Malaria Falsiparum Tanpa Komplikasi Di Kalimantan dan Sulawesi | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Efikasi dan Keamanan Dihidroartemisinin-Piperakuin (DHP) pada Penderita Malaria Falsiparum Tanpa Komplikasi Di Kalimantan dan Sulawesi

Hadjar Siswantoro - Personal Name; Emiliana Tjitra - Personal Name; Armedy Ronny Hasugian - Personal Name; Yenni Risniati - Personal Name; Rossa Avrina - Personal Name;

Since 2008, Dihydroartemisinin-Piperaquine (DHP) has been used as the first-line drug for treatment of falciparum malaria in Papua, which gradually will also be used in other endemic areas. The objective of the study was to determine the safety and efficacy of DHP. Patients with uncomplicated malaria due to Plasmodium falciparum were enrolled and treated with supervised DHP (arterakin ®, no. batch 010 909) daily dose for three days. Patients were followed for 42 days. Patients during follow up did physical examination and checked for microscopic parasites, measurement of hemoglobin levels (day 0, 14, 28 and 42), making the blood spot PCR (day 0 and day relapse), pregnancy test for women of childbearing age (Day 0 and 28). 119 patients were enrolled in the study. Therapeutic efficacy of DHP by day 42 in ITT and PP population were 98.3% (95% CI: 94.1-99.5%) and 100% (95% CI: 96.9-100%). The means of parasite clearance and fever clearance were 1.0 day and 1.6 days, and clinical symptoms was reduced by over 50% by day-7 follow up. All patients with gametocytes on day 0, generally were cleared on day 28 . There were an increasing number of patients with recovery hemoglobin at day 14, 28 and 42: 61%, 78% and 84%. Adverse events were mild, ie cough (31%) and abdominal pain (10%). Dihydroartemisinin-piperaquine was safe and effective for the treatment of uncomplicated P. falciparum malaria.

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Location name is not set Media Penelitian dan Pengembangan Kesehatan Vol.21

A0002730

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Series Title: -
Call Number: Media Penelitian dan Pengembangan Kesehatan Vol.21
Publisher: Jakarta : Sekretariat Badan Litbangkes., 2011
Collation: -
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ISBN/ISSN: 0853-9987
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Subject(s): malaria
plasmodium falciparum
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