Text

EphB4 Immunoexpression in Endometrial Cancer

---

Endometrial cancer is one of the most invasive gynaecological malignanccies. Hormonal imblance has several causes, one of which is the excessive estrogen exposure. The imbalance has been linked to the development of endometrial hyperplasia, which is the largest member of the tyrosine kinases receptor. Activation of EphB4 receptor by ephrin-B2 ligans is through to play an important role in the embryogenesis and the morphogenic processes of various adult organs, including the endometrium. Its role is also significant in the oncogensis of various tissues. An immunothistochemistry study was conducted by using EphB4 antibody to analyze 30 endometrial cancer samples. He study aims to expose the distribution and intensity of the immunoexpression of EphB4 in well, moderately and porly differentiated endometrial cancers, and to find the correlation between the immunoexpression of EphB4 and the grading of endometrial cancer. The result showed that EphB4 receptor was expressed at the luminal surfaces, cellmembrane and cytoplasm of the glandular epithelial cells. There were no significant differences in the distribution of EphB4 expressing cells of these there variables, but we observed significant differences (p

---

Ketersediaan

Informasi Detail

Judul Seri

-

No. Panggil

Jurnal Kedokteran Maranatha; 10(2)2011: 134-141

Penerbit

Bandung : Fakultas Kedokteran Universitas Kristen Maranatha., 2011

Deskripsi Fisik

7p.

Bahasa

ISBN/ISSN

1411-9641

Klasifikasi

-

Tipe Isi

-

Tipe Media

-

Tipe Pembawa

-

Edisi

-

Subjek

endometrium
CARCINOMA
ENDOMETRIAL NEOPLASMS

Info Detail Spesifik

-

Pernyataan Tanggungjawab

-

Versi lain/terkait

Lampiran Berkas

Komentar

---

Anda harus masuk sebelum memberikan komentar