Endometrial cancer is one of the most invasive gynaecological malignanccies. Hormonal imblance has several causes, one of which is the excessive estrogen exposure. The imbalance has been linked to the development of endometrial hyperplasia, which is the largest member of the tyrosine kinases receptor. Activation of EphB4 receptor by ephrin-B2 ligans is through to play an important role in the e…