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Polimorfisme Gen MMP-9, ekspresi MMP-9, dan Indeks Apoptosi Sel Serviks pada Kehamilan 21-26 minggu

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Over expression and premature activation of matrix metalloproteinase (MMP) can lead to degradation of amnion
chorionic membrane which clinically called premature rupture of membrane (PROM). Increasing MMP activity caused by matrix metalloproteinase-9 (MMP-9) gene polymorphism (C-1562T) will be followed by apoptosis. This study was aimed to find the differences between MMP-9 expression and cervical apoptotic index (AI) and also MMP-9 (C-1562T) polymorphism on 21–36 weeks of pregnancy with or without PROM. This was case control study and conducted in Dr. Hasan Sadikin Hospital and Bandung Networking Hospitals (May−November 2009). There were no significant correlation between MMP-9 expression and cervical AI in every variable on both groups. Three cases of PROM were found in mothers below 20 years of age. Women with 28−34 weeks of pregnancy had a greater risk for PROM than 21−28 weeks. Pregnant women with body mass index (BMI) 19−26, had risk to have PROM. Only one sample that showed a MMP-9 (C-1562T) polymorphism in the premature labor with PROM group. It can be concluded that there are no significant correlation between MMP-9 expression and cervical cells AI on both groups as well as MMP-9 (C-1562T) polymorphism which can alter MMP-9 expression.

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Series Title

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Call Number

Majalah Kedokteran Bandung, 43 (4) 2011 : 199-206

Publisher

Bandung : FK. Universitas Padjadjaran., 2011

Collation

7p.

Language

ISBN/ISSN

0126-074X

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

pregnancy
POLYMORPHISM, GENETIC
MATRIX METALLOPROTEINASE 9
CERVICAL

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