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Optimasi Formula Tablet Gastroretentive Ranitidin HCl dengan Sistem Floating (Optimization Formula gastroetentive Tablet of Ranitidine HCl with floating System)

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Ranitidine HCI is an H-2 receptor antagonista for the treatment of peptic gastric secretion with small biovailability, so that should be developed in a sustained release dosage form are retained in the stomach. Ranitidine HCl floating tablet was formulation by effervescent system. Simplex lattice design was applied to optimize the formula of ranitidine HCl floating tablet by varying levels of Methocel K15M 100-185 mg, sodium bicarbonate 15-100 mg, and citric acid 0-85 mg. The optimum formula determined by superimposed contour plot from various parameters: flowability of granules, physical properties of tablet and drug release using Design-expert program . Based on superimposed contour plot obtained optimum formula for the area in the range of methocel K15M 100-145 mg, sodium bicarbonate 20-80 mg and citric acid 2580 mg.

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Majalah Farmasi Indonesia: 22(2) 2011:106-114

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2011

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8p.

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0126-1037

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