Ranitidine HCI is an H-2 receptor antagonista for the treatment of peptic gastric secretion with small biovailability, so that should be developed in a sustained release dosage form are retained in the stomach. Ranitidine HCl floating tablet was formulation by effervescent system. Simplex lattice design was applied to optimize the formula of ranitidine HCl floating tablet by varying levels of …
Captopril has only 6-8 h duration of antihypertensive action, most stable at acidic condition and as the pH increased, it becomes unstable and undergoes a degradation reaction.These facts indicate a promising potential of the captopril floating system as an alternative to the conventional dosage form.The objective of the recent investigation was to find an optimum formula of floating tablet for…