Sintesis dan Uji Sitotoksisitas Senyawa LR-2 pada Sel Kanker Payudara T47D (Synthesis and Cytotoxicity Test of LR-2 on Breast Cancer Cell Line T47D) | Perpustakaan Badan Kebijakan Pembangunan Kesehatan

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Sintesis dan Uji Sitotoksisitas Senyawa LR-2 pada Sel Kanker Payudara T47D (Synthesis and Cytotoxicity Test of LR-2 on Breast Cancer Cell Line T47D)

Ritmaleni - Personal Name; Sismindari - Personal Name; Dina Anitasari - Personal Name; Rumiyati - Personal Name;

LR-2 is a compound analog of monastrol, an anticancer agent, which has been succesfully synthesised through the application of Biginelli reaction and one of LR compound series that synthesised in faculty of Farmacy, Universitas Gadjah Mada. This research was aimed to synthesized the LR-2 compound and to investigate the cytotoxicity of LR-2 on breast cncer cell line. The reaction was carried out by using the one pot reaction method. In this reaction benzaidehyde, 2-indanone and thourea were reacted together for 6 hours in acid catalyst. The cytotoxicity test was carried by using breast cancer cell line the MTT assay method and the LC50 was ditermined by using the probit analysis with miller and Tainter method. The product was isolated by using preparative TLC in 54% yield. The structure was elucidated by spertroscopy methods (UV-Vis, H-NMR, IR and GC-MS). The LC50 is 159 µM.

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Location name is not set Jurnal Kesehatan; 9(1)2011: 52-60

A0001794

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Detail Information

Series Title: -
Call Number: Majalah Farmasi Indonesia,22(1)2011:21-32
Publisher: Yogyakarta : Fakultas Farmasi UGM., 2011
Collation: 11p.
Language
ISBN/ISSN: 0126-1037
Classification: -
Content Type: -
Media Type: -
Carrier Type: -
Edition: -
Subject(s): Breast Neoplasm
CYTOTOXINS
Cell Line
Specific Detail Info: -
Statement of Responsibility: -

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