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Sintesis dan Uji Sitotoksisitas Senyawa LR-2 pada Sel Kanker Payudara T47D (Synthesis and Cytotoxicity Test of LR-2 on Breast Cancer Cell Line T47D)

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LR-2 is a compound analog of monastrol, an anticancer agent, which has been succesfully synthesised through the application of Biginelli reaction and one of LR compound series that synthesised in faculty of Farmacy, Universitas Gadjah Mada. This research was aimed to synthesized the LR-2 compound and to investigate the cytotoxicity of LR-2 on breast cncer cell line. The reaction was carried out by using the one pot reaction method. In this reaction benzaidehyde, 2-indanone and thourea were reacted together for 6 hours in acid catalyst. The cytotoxicity test was carried by using breast cancer cell line the MTT assay method and the LC50 was ditermined by using the probit analysis with miller and Tainter method. The product was isolated by using preparative TLC in 54% yield. The structure was elucidated by spertroscopy methods (UV-Vis, H-NMR, IR and GC-MS). The LC50 is 159 µM.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Farmasi Indonesia,22(1)2011:21-32

Penerbit

Yogyakarta : Fakultas Farmasi UGM., 2011

Deskripsi Fisik

11p.

Bahasa

ISBN/ISSN

0126-1037

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

Breast Neoplasm
CYTOTOXINS
Cell Line

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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