Ribosome Inactivating Proteins (RIPs) are compounds isolated from plants with ability to inhibit protein synthesis. The inhibition of protein synthesis is due to inactivation of ribosomal RNA through a site-specific deadenylation mediated by RNA N -g lycosid a se . Reportedly, RIPs mainly possess wide range of bioactivity including antiviral activity against plant infections. Other activities o…
Bruguiera gymnorhiza is one of the mangrove plant that has not been widely studi ed as a potential anti cancer. Previous research has suggested that the methanol extract of stem bark of B. gymnorhiza was cytotoxic against HeLa cells. The purpose ofthis study was to determine the cytotoxic effect and llPoptosis induction of chloroform fraction from the stem bark of B. gymnorhiza on HeLa cells.…
Bruguiera gymnorhiza is one of the mangrove plant that has not been widely studied as a potential anticancer. Previous research has suggested that the methanol extract of stem bark of B. gymnorhiza was cytotoxic against HeLa cells. The purpose ofthis study was to determine the cytotoxic effect and apoptosis induction of chloroform fraction from the stem bark of B. gymnorhiza on HeLa cells. The …
LR-2 is a compound analog of monastrol, an anticancer agent, which has been succesfully synthesised through the application of Biginelli reaction and one of LR compound series that synthesised in faculty of Farmacy, Universitas Gadjah Mada. This research was aimed to synthesized the LR-2 compound and to investigate the cytotoxicity of LR-2 on breast cncer cell line. The reaction was carried out…
Mirabilis jalapa L. contains basic (MJ30) and acidic (MJC) Ribosome-inactivating proteins (RIPs). Further purification of MJC has been found two RIPs, MJCO.3 and MJCO,5' This study is aimed to prove the cytotoxic selectivity of MJCO.3and MJCO.5against many cancer cell-lines and normal cell line. The two RIPs, MJCo,jend MJC05 were tested their cytotoxic effect on 8 human cancer cell lines and no…