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Concentration of Serum HER-2/neu as Pronostic Factor in Locally Advanced Breast Cancer (LABC) and Metastic Beast Cancer (MBC)

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Aim: to determine whether serum HER-2/neu level could be used as a prognostic factor in locally advanced breast cancer (LABC) and metastatic breast cancer (MBC).

Methods: a prospective cohort study was done in LABC and MBC patients in dr. Sardjito Hospital Yogyakarta from April 2006 to March 2008. Serum concentration of HER-2/neu was measured by ELISA done before and after chemotherapy. HER-2/neu expression tissue examination was done by immunohistochemistry. The clinical responses on therapy, survival and progression were recorded.

Results: twenty seven cases were obtained. Average concentration of serum HER-2/neu was 21.02+7.1 ng/ml. The level of serum HER-2/neu in LABC was lower than MBC (17.21 ng/ml vs 28.64 ng/ml; p=0.32). Average concentration of serum HER-2/neu in partial responders was 13.20 ng/ml (95% Cl 0.142 – 26.25), stable responders was 19.42 ng/ml (95% Cl – 0.255 – 39.09) and 29.35 ng/ml(95% Cl 1.95 – 56.74) in progressors (p=0.468). Patients with better clinical response had a lower average HER-2/neu serum level (16.12 ng/ml vs 29.35 ng/ml; p=0.247). HER-2/neu over expression was found in 40.7% of the tissues, 44% of LABC and 33.3% of MBC tissues (p=0.692). Negative HER-2/neu tissue protein expression had better clinical response (75% vs 45.5% p=0.224), and longer survival (p=0.08).

Conclusion: neither the expression of HER-2/neu in the tissue nor the level of serum HER-2/neu can be used as clinical prognosis factor on advanced stage breast cancer in our study population.

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Series Title

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Call Number

Actamedica Indonesia, 43(1)2011: 23-28

Publisher

Jakarta : Indonesia Journal of Medicine., 2011

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Language

English

ISBN/ISSN

0125-9326

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Subject(s)

breast neoplasms
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