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The Correlation of Decreased E-Cadherin and Beta-Integrin Expression with the Depth of Myometrial Inavasion and Pelvic Lymph Node Metastasis in Resectable Endometrical Cancer

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Objective: The purpose of this study was to determine the cor-relation between decreased E-Cadherin and Bf-integrin expression in resectable endometrial cancer with the depth of myometrial inva¬sion and pelvic lymph node metastasis.
Method: This was a cross sectional study, we used immunohis-tochemistry examination on E-Cadherin and Bt-integrin expression in resectable endometrial cancer patients who had surgery in 1997 to 2006 in Dr. Cipto Mangunkusumo Hospital and searched the cor¬relation with the d~th of myometrial invasion and pelvic lymph node metastasis.
Result: The prevalence of endometrial cancer from 1997 to 2006 in Dr. Cipto Mangunkusumo Hospital was 7.0 in a year. Out of 64 patients with endometrial cancer only 36 paraffin block could be found and immunostaioing on E-Cadherin and j3l-integrin was done in 30 samples. Decreased E-Cadherin and Bl-integrin expression was associated with the depth of myometrial invasion, pelvic lymph node metastasis, lymph ovascular space involvement and degree of differentiation in resectable endometrial cancer patients.
Conclusion: Decreased E-Cadherin and Bl-integrin expression was associated with the depth of myometrial invasion and pelvic lymph nodes metastasis.

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Detail Information

Series Title

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Call Number

Majalah Obstetrics dan Ginekologi Indonesia;34(3)2

Publisher

Jakarta : Indonesian Society of Obstetrics and Gynecology., 2010

Collation

6p.

Language

English

ISBN/ISSN

0303-7924

Classification

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Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

ENDOMESTRIAL NEOPLASMS
NEOPLSMA METASTASIS
PELVIC NEOPLASMS
MYOMETRIUM

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