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Radiodinasi Andrografolid dan Biodistrik-Businya dalam Mencit untuk Perunut Inflamasi (Radioiodination of Andrographolide and its Biodistribution in Mice for Inflammatory Tracer)

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Andrographolide, a bioactive component of Andrographis panicuiata (Burm.F) Nees, is the major lactone diterpenoidal bicyclic constituent in this plant which has proven to exert anti-inflammatory activity in vitro which was occurred via several mechanism, e.g inhibition of inducible nitric oxide synthase (iNOS), inhibition of radical oxygen species, and inhibition of NF-kappaB activation, The labeling with radlonuclide is often used for therapy, detection and quantlflcatlon of metabolites in the body. Even though the metabolites are very low in concentration they can be detected by the energy they emitted. Radionuclide can be used as radiotracer to detect whether drug really interacts with its target. The objective of this research is to synthesize 13'I-labelled andrographolide and to study its biodistrlbution In mice to understand the location of Its organ target, Indirect radiolodlnation of andrographolide was carried out by using bromine as the leaving group and followed by fast Iodination at 40 QC, yielded 72.6 % purity of the labeled compound. Iodination was occurred through proton substitution at C-12. Then the androqrapholtde-V'] was Injected Into lateral vein of mice's tall to study its biodlstrlbutlon. The compound was distributed In all organs with the highest accumulation occurred

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Series Title

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Call Number

Majalah Farmasi Indonesia;21(4)2010:271-278

Publisher

Yogyakarta : Fakultas Farmasi UGM., 2010

Collation

7p.

Language

ISBN/ISSN

0126-1037

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Edition

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Subject(s)

anti-inflammatory agents

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