Andrographolide, a bioactive component of Andrographis panicuiata (Burm.F) Nees, is the major lactone diterpenoidal bicyclic constituent in this plant which has proven to exert anti-inflammatory activity in vitro which was occurred via several mechanism, e.g inhibition of inducible nitric oxide synthase (iNOS), inhibition of radical oxygen species, and inhibition of NF-kappaB activation, The la…