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Sintesis dan Uji Sitotoksik in Vitro Senyawa 2-Hidroksinkotinil Oktilamida terhadap Sel Kanker Leukemia Murin P388 (Synthesis and in Vitro Cytotoxic Activity Test of2-Hidroxynicotinoyl-Octylamide on Murine Leukemia P-388 Cells)

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The novel compounds of 2-hydroxynicotinyl octylamide (NOA) were synthesized by modifying of the UK-3A compound known biologically active to inhibit bacterial and cancer cell growth. Synthesis of 2-hydroxynicotinyl octylamide (NOA) were carried out in one step reaction for the second compound. NOA was synthesized by amidation reaction between 2-hydroxynicotinic acid and octylamin yielded 76.1% of the product. The compound werll confirmed with Fourier transformed infrared spectrophotometry, liquid chromatography mass spectroscopy, and nuclear magnetic resonance spectrometry. In vitro test on breast cancer T 470 demonstrated that the inhibition the growth of cancer cells with IC", for NOA were 32.0 fig/mL. The IC", values indicated that the synthesis products were sufficiently potential to be anticancer for murine leukemia P388 cells.
Keywods: anticancer, UK-3A analog, NOA, murine leukemia P388.

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Framasians;1(2)2010:95-100

Publisher

Jakarta : Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Muhammadiyah Prof Dr. Hamka., 2010

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2069-6968

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Subject(s)

LEUKEMIA VIRUS, MURINE

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