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Cytotoxic Selectivity of MJC0.3 and MJC0.5, Acidic Ribosome-Inactivating Proteins Isolated from Mirabilis Jalapa L. Leaves Againts Various Cancer Cell-Lines

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Mirabilis jalapa L. contains basic (MJ30) and acidic (MJC) Ribosome-inactivating proteins (RIPs). Further purification of MJC has been found two RIPs, MJCO.3 and MJCO,5' This study is aimed to prove the cytotoxic selectivity of MJCO.3and MJCO.5against many cancer cell-lines and normal cell line. The two RIPs, MJCo,jend MJC05 were tested their cytotoxic effect on 8 human cancer cell lines and normal cell using MTT assay compared with MJC protein. The highest cytotoxic activities of MJCO.3 and MJCO.5 were against EVSA-T followed by T47D, HeLa, WiDR, SiHa, Raji, NS1, and MCF7, with the IC50 of 59.3,102.4,162.9,190.5,249.5, and 304.5 ~g/mL, respectively for MJCo,J and 32.8, 75.5, 86.0, 108.3, 346.7, and 220.06 ~g/mL, respectively for MJCo.s. Based on these ICso values, MJC03 and MJC05 were specific to EVSA-T and T47D, whereas they were not selective against Raji and SiHa (SI < 10.0). It can be concluded that he acidic RIPs isolated from M. jalapa L. leaves was potential to be developed as anticancer agents for breast cancer.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Journal of the Medical Sciences:42(1)2010:39-43

Penerbit

Yogyakarta : Fakulty of Medicine Gadjah Mada University., 2010

Deskripsi Fisik

4p.

Bahasa

English

ISBN/ISSN

0126-1312

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

plants, medicinal
CYTOTOXINS
Ribosomal Protein

Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

Lampiran Berkas

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