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Pembuatan Garam Ibuprofen dan Aplikasinya dalam Sediaan Tablet (Ibuprofen Salt Production and its Application in Tablet Dosage Form)

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Ibuprofen is an anti-inflammatory drug and is practically insoluble in water. The low melting point and the por flowability of ibuprofen can lead to process difficulty in tablets production. The purpose of this research was to make the sodium salt from of ibuprofen which has better solubility in water. Sodium ibuprofen salt was prepared by reacting the ibuprofen and sodium hydroxide, then characterized using TG/DTA, DSC, spectrophotometer UV-VIS, spectrophotometer IR, X-ray diffraction, and SEM. Tablets were prepared by wet granulation method. The characterization result showed that sodium ibuprofen result of the synthesis was dehydrate form with melting point of 199,9⁰C. Granules of sodium ibuprofen result of the synthesis had better flowability and bigger density than ibuprofen granules. The physical characterization of the tablet showed that the formula of sodium ibuprofen resulted from the sodium ibuprofen showed the higher release rate than ibuprofen so can give quicker onset of action.

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Ketersediaan

Informasi Detail

Judul Seri

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No. Panggil

Majalah Farmasi Indonesia:20(3):141-150

Penerbit

Yogyakarta : Fakultas Farmasi UGM., 2009

Deskripsi Fisik

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Bahasa

ISBN/ISSN

0126-1037

Klasifikasi

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Tipe Isi

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Tipe Media

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Tipe Pembawa

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Edisi

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Subjek

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Info Detail Spesifik

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Pernyataan Tanggungjawab

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Versi lain/terkait

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